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General and Specialized Biochemistry Image Biochimie
2023 EQA SCHEMES
EQA 2023 - Serum Protein Electrophoresis (EPS)
Expert Biologists - Scheme Coordinators:
Magali DECHOMET and Christine LOMBARD
EQA performed since 2012
Number of participating laboratories in 2022: 433

1 - Scheme Overview

This external quality assessment scheme provides normal and disease-related electrophoretic profiles for assessing monoclonal gammopathy (paraproteinemia) diagnosis and type determination.

The reports include statistical processing of quantitative results and the analysis of qualitative results: interpretation of electrophoresis, immunofixation and immunotyping performed to identify a monoclonal band detected by electrophoresis.

Participating labs can choose to be assessed for all the analytes of this scheme, or simply a subset of analytes of interest.

2 - Assessment Frequency

Number of surveys per year: 8
Number of control samples per survey: 1
Number of samples per year: 8

3 - List of Analytes Assessed 

  • Total proteins
  • Free Kappa light chains
  • Free Lambda light chains
  • IgA
  • IgG
  • IgM
  • Protein electrophoresis
    • - Albumin
    • - α1-Globulins
    • - α2-Globulins
    • - β1-Globulins
    • - β2-Globulins
    • - γ-Globulins
  • Monoclonal gammopathy type determination

4 - Description of the Control Samples

Lyophilized (samples to be resuspended in 3 mL of distilled water) or liquid (1 mL ready-to-usehuman control serums

5 - Clinical Cases

Clinical cases are provided with each investigation.

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