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Association for the Promotion of Quality Control in Medical Biology
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IQC 2023 - Hemostasis (HMPE)
Expert Biologists - Scheme Coordinators:
Chantal Bon and Roland Meley
IQC performed since 1975
Number of participating laboratories in 2022: 37

1 – Scheme overview

This internal quality control scheme is intended to monitor the trueness and intermediary repeatability of the most common hemostasis tests.

The target values and acceptable limits for each peer group are defined based on the previous year’s EQA schemes provided at the beginning of the scheme (target values are set by the results of 630 laboratories).

Individual, customized statistics (externalized IQC) can be provided, together with an assessment of the quality of the results (trueness and intermediary repeatability). At the end of the year, you will receive a customized summary report with graphics.

You can enter your results (N, mean and CV only) directly on our website.

Control samples are CE marked in accordance with European directive 98/79 EC and French law.

2 levels of assessment are provided for all the analytes tested:

  • Level 1: normal values for hemostasis analytes
  • Level 2: disease-related values of hemostasis analytes
Analyzes Level 1 :
Normal level
Level 2 :
Disease-related level
Prothrombin time (in seconds, % and INR) 70 to 100% 30 to 50%
Activated Partial Thromboplastin Time (aPTT), PTTK <40 seconds 50 to 70 seconds
Fibrinogen 2.5 to 3.5 g/L 1.0 to 1.5 g/L
Antithrombin 80 to 130% 30 to 60%
PT factors (II, V, VII and X) 70 to 125% 30 to 60%
aPTT factors (VIII, IX, XI and XII) 70 to 125% 30 to 60%
Protein C, Protein S and Free Protein S 70 to 130% 30 to 60%

Samples are provided in kits of 24 vials, which once resuspended, contain 1 mL.

2 – List of analytes assessed

  • Prothrombin time (in seconds, % and INR)
  • Activated Partial Thromboplastin Time (aPTT)
  • Partial Thromboplastin Time with Kaolin (PTTK)
  • Fibrinogen
  • Antithrombin
  • PT factors (II, V, VII and X)
  • aPTT factors (VIII, IX, XI and XII)
  • Protein C, Protein S and Free Protein S

3 – Description of the control samples

Lyophilized human plasma (citrate) (samples to be resuspended in 1 mL of distilled water).

IQC expiry date - Hemostasis 2023: 2024-06

4 – Storage of reconstituted samples

  • 8H from +2°C to +8°C
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