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General and Specialized Biochemistry Image Biochimie
2023 EQA SCHEMES
EQA 2023 - Immunoassay (CIPO)
Expert Biologists - Scheme Coordinators:
Laurence CHARDON, Karim CHIKH and Marie LOPEZ
EQA performed since 1977
Number of participating laboratories in 2022: 860

1 - Scheme Overview

This external quality assessment allows the control of immunoassays with hormone markers and tumor or metabolic markers. This scheme brings together 60 analytes distributed over 11 sub-schemes.

The most commonly assayed analytes are offered in the CIMD scheme. The more specialized analytes are offered in the CIMA, CIMB, CIME, CIMF, CIMG, CIMH, CIMN, CIMR, CIMT and CIMV programs (see Table below).

The determination of the acceptable limits is based on the use of biological variations.

Participating labs can choose to be assessed for all the analytes of this scheme, or simply a subset of analytes of interest.

2 - Assessment Frequency

Number of surveys per year: 6
Number of control samples per survey: 2
Number of samples per year: 12 (except for the CIMG scheme: 9 samples)

3 - List of Analytes Assessed 

Sub-scheme Analytes assessed
CIMA Anti TG, Anti TPO and Osteocalcin
CIMB AMH and Inhibin B
CIMD ACE, AFP, β2 microglobulin, CA 125, CA 15-3, CA 19-9, Cortisol, DHT (dihydrotestosterone), EPO, Estradiol, Ferritin, Folates, FSH, hCG, hGH, total IgE, Insulin, LH, Parathormone, C-Peptide, Progesterone, Prolactin, S100B Protein, Free PSA, Total PSA, Free T3, Free T4, Testosterone, TSH and Vitamin B12
CIME 17α OH-Progesterone, Δ4 Androstenedione, Aldosterone, DHEA, DHEA-Sulfate, IGF1, IGFBP-3 and SHBG or TeBG
CIMF CA 72-4, Cyfra 21-1, NSE, free βhCG subunit and Thyroglobulin.
CIMG Glucagon
CIMH ACTH
CIMN Calcitonin
CIMR ARP, Renin, 11-Deoxycortisol, Corticosterone and Deoxycorticosterone
CIMT Free Testosterone and Gastrin
CIMV 25(OH) Vitamin D and 1-25 (OH)2 Vitamin D

For EPO, S100B Protein and DHT (dihydrotestosterone) : 4 surveys per year.

4 - Description of the Control Samples

Lyophilized human control serum (with the exception of CIMG samples for Glucagon) . The samples are to be resuspended in :

  • 3 mL of distilled water for the CIMD and CIME sub-schemes
  • 1 mL of distilled water for CIMA, CIMB, CIMF, CIMH, CIMN, CIMR, CIMT and CIMV sub-schemes
  • 0.5 distilled water for the CIMG sub-scheme
panneau attention For the CIMD sub-scheme, we advise laboratories testing more than 18 analytes to order an additional kit.
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